HerpesFolds

This table gives interactive access to the complete predicted structures of all 9 human herpesviruses using the following proteomes: HSV-1 strain 17 (UP0000009294), HSV-2 strain HG52 (UP000001874), VZV strain Dumas (UP000002602), HCMV strain Merlin (UP000000938), HHV-6A isolate U1102 (NC_001664), HHV-6B strain Z29 (NC_000898), HHV-7 strain RK (NC_001716), EBV strain B95-8 (UP000153037) as well as KSHV strain GK18 (UP000000942).

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Please use the search field on the top of the table for super-fast access to the database. You can enter the gene name, protein name, description key word, or structure group key word.

Each row of the table shows the known homologous relationships between viruses (Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis by Edward S. Mocarski Jr.).

We have used FoldSeek to cluster all human herpesvirus protein predictions into structural similarity clusters. These clusters encompass new connections between proteins, and each was given a “Structure Group” name to describe the most similar cellular (i.e. dihydrofolate reductase) or viral protein (i.e. tegument protein 3). For particularly large groups, a second part was added to the name to denote the subcluster based on a protein (i.e. immunoglobulin glycoprotein_RL11) or number of domains (i.e. US22_4).

Searching a “Structure Group” name will display proteins that were found to be structurally similar. The following proteins failed the quality scores and were therefore not found in the associated “Structure Group”: HCMV_UL44, HHV-6A_UL44, HSV-2_UL36, and HSV-2_UL51.

For help evaluating the predictions, please check this quick tutorial.

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All predictions as well as accompanying data for our HerpesFolds manuscript is available at:

Soh, T., & Bosse, J. (2024). HerpesFolds: A proteome-wide structural systems approach reveals insights into protein families and activities of all nine human herpesviruses. Zenodo. https://doi.org/10.5281/zenodo.13284140